Alzheimer's Drug Discovery Foundation (ADDF)

Founded in 1998 by co-chairmen Leonard A. and Ronald S. Lauder, the Alzheimer’s Drug Discovery Foundation (ADDF) is the only charity solely focused on finding drugs for Alzheimer’s.

ADDF Core Programs 

Drug Development RFP

Scope: The Drug Development RFP seeks to support in vivo preclinical studies that advance lead molecules developed for Alzheimer’s disease and related dementias to IND-enabling studies. The proposed studies should be structured to deliver a compound with strong potential for clinical and commercial application. This funding opportunity prioritizes novel drug mechanisms and modes of action related to the biology of aging and other emerging therapeutic areas for dementia. For this reason, amyloid targeted approaches and cholinesterase inhibitor proposals will not be considered for this RFP.

Subsidy: Max $600,000

Funding rate: 100%

Deadlines: 1st stage (Letter of Intent): 20 May/30 September 2022

2nd stage (invited full proposal): 22 July/2 December 2022

Project duration: Multi-year; potential for follow-on funding

Learn more on the ADDF website

Program to Accelerate Clinical Trials (PACT)

Scope: The PACT RFP supports IND-enabling studies and early-phase clinical trials that test promising pharmacological interventions and devices for Alzheimer’s disease (AD) and related dementias. Both disease-modifying and symptomatic agents will be considered.

Subsidy: Max $3 million

Funding rate: 100%

Deadlines: 1st stage (LOI): 20 May/30 September 2022

2nd stage (invited full proposal): 22 July/2 December 2022

Project duration: Multi-year; potential for follow-on funding

Learn more on the ADDF website

Neuroimaging and CSF Biomarker Development RFP

Scope: The aim of this RFP is to further develop and validate established biomarkers for which there is a clear clinical need in Alzheimer’s disease and related dementias. This RFP prioritizes biomarkers with a defined context of use, a clear advantage over other relevant biomarkers, and a path to commercialization and/or clinical use.

Specifically, this RFP focuses on:

• developing novel PET ligands for clinical trials
• supporting novel CSF biomarkers
• validating established MRI approaches in larger cohorts

Subsidy: max $600,000

Funding rate: 100%

Deadlines: 1st stage (LOI): 20 May/30 September 2022

2nd stage (invited full proposal): 22 July/2 December 2022

Project duration: Multi-year; potential for follow-on funding

Learn more on the ADDF website

Prevention Pipeline RFP

Scope: The ADDF seeks to support comparative effectiveness research, prevention clinical trials, and epidemiological studies that probe whether the use or choice of drugs alters the risk for dementia or cognitive decline.

Specifically, the Prevention Beyond the Pipeline program supports:

• Studies Leveraging the Consortium of Cohorts for Alzheimer’s Prevention Action (CAPA);
• Comparative Effectiveness Research;
• Studies of Cognitive Decline and Cognitive Reserve.

Subsidy: $50,000-100,000 for epidemiological analyses; up to $3,000,000 for clinical trials

Funding rate: 100%

Deadlines: 1st stage (LOI): 20 May/30 September 2022

2nd stage (full proposal): 22 July/2 December 2022

Project duration: Multi-year; potential for follow-on funding

Scope: The ADDF seeks to support comparative effectiveness research, prevention clinical trials, and epidemiological studies that probe whether the use or choice of drugs alters the risk for dementia or cognitive decline.

Specifically, the Prevention Beyond the Pipeline program supports:

• Studies Leveraging the Consortium of Cohorts for Alzheimer’s Prevention Action (CAPA);
• Comparative Effectiveness Research;
• Studies of Cognitive Decline and Cognitive Reserve.

Learn more on the ADDF website

About Alzheimer’s Drug Discovery Foundation (ADDF)

The ADDF focuses on translating the knowledge they have gained about the causes of Alzheimer’s disease into drugs to conquer it. They support an underfunded area—preclinical drug discovery and early-stage clinical trials of potential drug targets—that is often called the “valley of death” because it’s where good ideas go to die. These projects hold great promise, but also great risk.

And most are not far enough along in the drug development pipeline to attract financial support from the pharmaceutical industry, federal funders, or other major partners. By assuming the risk and bridging this critical gap in funding, the ADDF enables leading scientists to pursue pioneering ideas to cure Alzheimer’s disease that would otherwise go unexplored.

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Visit the ADDF website for more information

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