KWF Research & Implementation

The KWF Research & Implementation programme 2022 consists of two calls covering exploration research and development & implementation in the field of cancer. On this page we provide an overview of these upcoming calls from KWF. For further information, contact our funding experts.

New calls from KWF: focusing on the following topics and divided over 2 calls for proposals (Exploration and Development & implementation):

1. Evidence of carcinogenic effect of environmental factors
2. Techniques that shift diagnostics to peripheral care
3. Evidence-based control in palliative care
4. Clinical studies aimed at the further development of drugs and treatments in oncological indications with a small patient group

KWF Research & Implementation Calls 2022

Exploration research

Deadline: expected end of April/early May 2022

Basic research: The goal of basic research is to obtain essential insight into the origin and progression of cancer and its (psychosocial) effects, as well as basic principles underlying the prevention and treatment of cancer and relevant technological developments. Basic research does not focus directly on the possible application of this knowledge.

Credentialing: Credentialing (or collecting credentials, evidence, confirmation) aims at identifying factors, targets and leads that could influence or improve prevention, diagnostics, treatment and quality of life. Examples are the discovery of drugs or biomarkers and compound or drug screening. Observational and population studies are also part of credentialing, including cross-sectional research, retrospective and/or prospective cohort studies and case-control studies. The credentialing phase includes a first step towards validating the identified factors, targets or leads

Development & Implementation

Deadline: 23 March 2022

Creation of modality: The goal is the extensive characterisation and further development of new inventions/modalities until there is sufficient (in vitro and in vivo) evidence from model systems or retrospective data and sample sets, to start preparing for human evaluation. The development of psychosocial interventions is included in this research phase. Human participation in the development of inventions/modalities is possible in this phase when it is not meant for a validation in a human setting. Starting from this research phase, concrete solutions for specific problems and needs (including unmet medical needs) are developed and validated.

Preclinical research: The goal of preclinical research is the completion of all stages required to start the clinical/human evaluation of a new invention/modality in subjects, such as:

• The development of GMP/clinical-grade production, toxicity testing, pilot or technical testing, successful IND/IMPD/CE submission and regulatory/ethical aspects;
• Prospective analyses of the clinical feasibility of an invention or modality without performing the actual intervention (e.g. prospective biomarker studies without changing the actual treatment).

Clinical research: The goal of clinical research is to realize prospective clinical research, such as:

• a prospective clinical evaluation of a new invention/modality or assay/tool using a limited number of subjects;
• establishing the effectiveness of a new invention, dosage, off-label usage, combinations of modalities or psychosocial treatment;
• changes to treatment regimens associated with existing methodologies (including population checks) in a patient population.

Implementation research: Implementation research encompasses scientific studies on methods to promote the delivery and enhance the adoption of evidence-based interventions in (clinical) practice aligning with the main goals of KWF. A project proposal must have a research focus, including a scientific research question. Eligible projects focus on any aspect of Implementation research, including the factors affecting implementation, the process of implementation and the results of implementation. This also includes how to introduce potential solutions into a (health) system or how to promote their large scale use and sustainability. The purpose is to understand what, why, and how evidence based interventions/new methods work in “real world” settings, and to test approaches in order to improve them.

Further reading on the KWF Research & Implementation Programme

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